Most Relevant Publications:

- Pellin D, Biasco L, Scala S, Di Serio MC, Wit EC Tracking hematopoietic stem cell evolution in a Wiskott-Aldrich clinical trial. Annals of Applied Statistics (2023). In press

- Pellin D*, Claudio N*, Guo Z, Ziglari T, Pucci F, Gene expression profiling of lymph node sub-capsular sinus macrophages in cancer. Frontiers in Immunology 12 (2021): 2150. PMID: 34168645 PMCID: PMC8218730 DOI: 10.3389/fimmu.2021.672123

- Pellin D, Biasco L, Aiuti A, Di Serio MC, Wit EC. Penalized inference of the hematopoietic cell differentiation network via high-dimensional clonal tracking. Applied Network Science. 2019 Dec 1;4(1):115.

- Pellin D*, Loperfido M*, Baricordi C, Wolock SL, Montepeloso A, Weinberg OK, Biffi A, Klein AM, Biasco L. A comprehensive single cell transcriptional landscape of human hematopoietic progenitors. Nature communications. 2019 Jun 3; 10(1): 2395. PubMed PMID: 31160568; PubMed Central PMCID: PMC6546699.

- Scala S*, Basso-Ricci L*, Dionisio F*, Pellin D*, Giannelli S, Salerio FA, Leonardelli L, Cicalese MP, Ferrua F, Aiuti A, Biasco L. Dynamics of genetically engineered hematopoietic stem and progenitor cells after autologous transplantation in humans. Nature medicine. 2018 Nov 1; 24(11): 1683-1690. PubMed PMID: 30275570.

- Pellin D, Di Serio C. A novel scan statistics approach for clustering identification and comparison in binary genomic data. BMC bioinformatics. 2016 Sep 22; 17(Suppl 11): 320. PubMed PMID: 28185547; PubMed Central PMCID: PMC5046198.

Complete List of Publications:

- Cornetta K, Lin TY, Pellin D, Kohn DB Meeting FDA Guidance Recommendations for Replication Competent Virus and Insertional Oncogenesis Testing. Molecular Therapy - Methods & Clinical Development. IMolecular Therapy-Methods & Clinical Development 28 (2023): 28-39 PMID: 36588821 PMCID: PMC9791246 DOI: 10.1016/j.omtm.2022.11.009

- Izotova N, Rivat C, Baricordi C, Blanco E, Pellin D, Watt E, Gkazi AS, Adams S, Gilmour K, Bayford J, Booth C, Gaspar HB, Thrasher AJ, Biasco L. 2021. Long-term lymphoid progenitors independently sustain naïve T and NK cell production in humans. Nature communications 12.1 (2021): 1-16. PMID: 33712608 PMCID: PMC7954865

- Demirci S, Zeng J, Wu Y, Uchida N, Shen AH, Pellin D, Gamer J, Yapundich M, Drysdale C, Bonanno J, Bonifacino AC, Krouse AE, Linde NS, Engels T, Donahue ER, Haro-Mora JJ, Leonard A, Nassehi T, Luk K, Porter SN, Lazzarotto CR, Tsai SQ, Weiss MJ, Pruett-Miller SM, Wolfe AS, Bauer DE, Tisdale JF. BCL11A enhancer–edited hematopoietic stem cells persist in rhesus monkeys without toxicity. The Journal of Clinical Investigation. 2020 Nov 9;130(12). PMID: 32897878 PMCID: PMC7685754

- Brendel C, Negre O, Rothe M, Guda S, Parsons G, Harris C, McGuinness M, Abriss D, Tsytsykova A, Klatt D, Bentler M, Pellin D, Christiansen L, Schambach A, Manis J, Trebeden-Negre H, Bonner M, Esrick E, Veres G, Armant M, Williams DA. Preclinical Evaluation of a Novel Lentiviral Vector Driving Lineage-Specific BCL11A Knockdown for Sickle Cell Gene Therapy. Molecular Therapy-Methods & Clinical Development. 2020 Mar 17. PubMed PMID: 32300607; PubMed Central PMCID: PMC7150438.

- Hsu JY, Fulco CP, Cole MA, Canver MC, Pellin D, Sher F, Farouni R, Clement K, Guo JA, Biasco L, Orkin SH, Engreitz JM, Lander ES, Joung JK, Bauer D, Pinello L. CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data. Nature methods. 2018 Dec 1; 15(12): 992-993. PubMed PMID: 30504875; PubMed Central PMCID: PMC6620603.

- Biasco L, Pellin D, Scala S, Dionisio F, Basso-Ricci L, Leonardelli L, Scaramuzza S, Baricordi C, Ferrua F, Cicalese MP, Giannelli S, Neduva V, Dow DJ, Schmidt M, Von Kalle C, Roncarolo MG, Ciceri F, Vicard P, Wit E, Di Serio C, Naldini L, Aiuti A. In Vivo Tracking of Human Hematopoiesis Reveals Patterns of Clonal Dynamics during Early and Steady-State Reconstitution Phases. Cell stem cell. 2016 Jul 7; 19(1): 107-19. PubMed PMID: 27237736; PubMed Central PMCID: PMC4942697.

- Lelek M, Casartelli N, Pellin D, Rizzi E, Souque P, Severgnini M, Di Serio C, Fricke T, Diaz-Griffero F, Zimmer C, Charneau P, Di Nunzio F. Chromatin organization at the nuclear pore favours HIV replication. Nature communications. 2015 Mar 6; 6: 6483. PubMed PMID: 25744187; PubMed Central PMCID: PMC4366494.

- Pellin D, Di Serio C. Clusters Identification in Binary Genomic Data: The Alternative Offered by Scan Statistics Approach. Computational Intelligence Methods for Bioinformatics and Biostatistics. Springer, Cham. 2014.

- Baldan R, Cigana C, Testa F, Bianconi I, De Simone M, Pellin D, Di Serio C, Bragonzi A, Cirillo DM. Adaptation of Pseudomonas aeruginosa in Cystic Fibrosis airways influences virulence of Staphylococcus aureus in vitro and murine models of co-infection. PloS one. 2014 Mar 6; 9(3): e89614. PubMed PMID: 24603807; PubMed Central PMCID: PMC3945726.

- Aiuti A, Biasco L, Scaramuzza S, Ferrua F, Cicalese MP, Baricordi C, Dionisio F, Calabria A, Giannelli S, Castiello MC, Bosticardo M, Evangelio C, Assanelli A, Casiraghi M, Di Nunzio S, Callegaro L, Benati C, Rizzardi P, Pellin D, Di Serio C, Schmidt M, Von Kalle C, Gardner J, Mehta N, Neduva V, et al. (40 authors). Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome. Science (New York, N.Y.). 2013 Aug 23; 341(6148): 1233151. PubMed PMID: 23845947; PubMed Central PMCID: PMC4375961.

- Moiani A, Miccio A, Rizzi E, Severgnini M, Pellin D, Suerth JD, Baum C, De Bellis G, Mavilio F. Deletion of the LTR enhancer/promoter has no impact on the integration profile of MLV vectors in human hematopoietic progenitors. PloS one. 2013 Jan 1; 8(1): e55721. PubMed PMID: 23383272; PubMed Central PMCID: PMC3561312.

- Di Serio C, Pellin D, Ambrosi A, Glad IK, Frigessi A. Biostatistics Meets Bioinformatics in Integrating Information from Highdimensional Heterogeneous Genomic Data: Two Examples from Rare Genetic Diseases and Infectious Diseases. Computational Intelligence Methods for Bioinformatics and Biostatistics. Springer, Berlin, Heidelberg. 2012.

- Miotto P, Forti F, Ambrosi A, Pellin D, Veiga DF, Balazsi G, Gennaro ML, Di Serio C, Ghisotti D, Cirillo DM. Genome-wide discovery of small RNAs in Mycobacterium tuberculosis. PloS one. 2012 Jan 1; 7(12): e51950. PubMed PMID: 23284830; PubMed Central PMCID: PMC3526491.

- Pellin D, Miotto P, Ambrosi A, Cirillo DM, Di Serio C. A genome-wide identification analysis of small regulatory RNAs in Mycobacterium tuberculosis by RNA-Seq and conservation analysis. PloS one. 2012 Jan 1; 7(3): e32723. PubMed PMID: 22470422; PubMed Central PMCID: PMC3314655.

- Ambrosi A, Glad IK, Pellin D, Cattoglio C, Mavilio F, Di Serio C, Frigessi A. Estimated comparative integration hotspots identify different behaviors of retroviral gene transfer vectors. PLoS computational biology. 2011 Dec 1; 7(12): e1002292. PubMed PMID: 22144885; PubMed Central PMCID: PMC3228801.

- Biasco L, Ambrosi A, Pellin D, Bartholomae C, Brigida I, Roncarolo MG, Di Serio C, von Kalle C, Schmidt M, Aiuti A. Integration profile of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell. EMBO molecular medicine. 2011 Feb 1; 3(2): 89-101. PubMed PMID: 21243617; PubMed Central PMCID: PMC3060339.

- Cattoglio C, Maruggi G, Bartholomae C, Malani N, Pellin D, Cocchiarella F, Magnani Z, Ciceri F, Ambrosi A, von Kalle C, Bushman FD, Bonini C, Schmidt M, Mavilio F, Recchia A. High-definition mapping of retroviral integration sites defines the fate of allogeneic T cells after donor lymphocyte infusion. PloS one. 2010 Dec 22; 5(12): e15688. PubMed PMID: 21203516; PubMed Central PMCID: PMC3008730.

- Cattoglio C, Pellin D, Rizzi E, Maruggi G, Corti G, Miselli F, Sartori D, Guffanti A, Di Serio C, Ambrosi A, De Bellis G, Mavilio F. High-definition mapping of retroviral integration sites identifies active regulatory elements in human multipotent hematopoietic progenitors. Blood. 2010 Dec 16; 116(25): 5507-17. PubMed PMID: 20864581.